![]() ![]() “Imagine this protein is the brake pedal and recovery is the gas pedal. “When this protein is high, it interferes with neurological recovery,” said lead author Andrea Tedeschi, assistant professor of neuroscience in Ohio State’s College of Medicine. The Ohio State University team previously found that gabapentin blocks the activity of a protein that, when expressed at elevated levels after an injury to the brain or spinal cord, hinders re-growth of axons, the long, slender extensions of nerve cell bodies that transmit messages. ![]() Functional recovery also continued after treatment was stopped, the researchers found. Results showed that daily gabapentin treatment for six weeks after a stroke restored fine motor functions in the animals’ upper extremities. The experiments mimicked ischemic stroke in humans, which occurs when a clot blocks blood flow and neurons die in the affected brain region. The drug gabapentin, currently prescribed to control seizures and reduce nerve pain, may enhance recovery of movement after a stroke by helping neurons on the undamaged side of the brain take up the signaling work of lost cells, new research in mice suggests. ![]()
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